Create exclusion query

I'm hoping there is a solution ot my question.  Currently, when I want to distribute software to my computers, I create a query to determine which computers need the software.  Generally, there are 20 or so that for one reason or another won't be getting the program installed.  Basically what I've been doing is this:

If SOFTWARE doesn't exist, AND computer name <> X, AND computer name <> Y, AND computer name <> Z.....  (twenty times).

I guess I'm asking if there is a better way to do this?  Can I have task that installs to one query (group of machines) but exclude a subset?

Thanks.